Abstract: Many recent studies indicate that the relationship between granitic pegmatite and granite is complex and can be summarized simply into four types: "Father-son relationship", i.e. granitic pegmatites are the late products of highly differentiated and evolved granitic magma; "Brotherly relationship", granitic pegmatite and granite are the products of simultaneous or near-simultaneous independent crystallization of magma with similar compositions; “Indirect relationship”, formation of rare metal pegmatites through multi-stage partial melting of source granite; “No relationship between granitic pegmatite and granite”, relative big time-gap and different source materials for pegmatite and granite are displayed in many pegmatite fields, and anatectic individual pegmatite magma is a reasonable genetic model. Crystal mush reservoir and trans-crustal magmatic system are the important for understanding the relationship between pegmatite and granite. Inheritance （or detrital） minerals for dating and isobaric interference for analysis of Hafnium isotopic composition should be pay more attention for the study on the relationship between pegmatite and granite. The establishment and development of techniques and reference materials for isotopic dating need to be enhanced. The study on characteristics and mechanism of non-traditional isotope fractionation during the differentiation and evolution of granitic magma should be strengthened. Petro-geochemical analysis and large-scale mapping of the granite batholith are suggested in order to give more valid evidences for the rare metal pegmatite exploration.