Abstract: The tectonic uplift of the northern foothill of the Qinling Mountains is of great significance for understanding its geological and ecological evolution. With the advancement of geological exploration techniques and the deepening of regional geological studies, more details of the tectonic uplift processes of the northern foothill of the Qinling Mountains have been gradually revealed. According to published low-temperature thermochronological data, at least three major cooling and exhumation episodes are revealed since the Late Cretaceous: a slow cooling during the Late Cretaceous (95-75 Ma), with a cooling rate of 2.8 ℃/Ma and a exhumation rate of 0.12 km/Ma, a rapid cooling during the Eocene-Oligocene (47-27 Ma), with a cooling rate of 6.1 ℃/Ma and a exhumation rate of 0.24 km/Ma, and a continuing slow cooling since the Late Miocene(10 Ma), with a cooling rate of 2.1 ℃/Ma and an exhumation rate of only 0.08 km/Ma, with the cooling and exhumation migrating towards the northeast.This migration trend is closely related to the tectonic expansion of the northeast margin of the Tibetan Plateau at about 10-8 Ma. Meanwhile, the adjacent Weihe Basin has been undergoing rapid sedimentation and subsidence since the Late Miocene (7.3 Ma), forming a distinctive tectonic response to the uplift of the northern foothill of the Qinling Mountains, which further confirms the linkage and synergistic evolution of the regional tectonic activities in the context of the northeastern margin of the Qinghai-Tibetan Plateau. These results indicate that the tectonic uplift of the northern foothill of the Qinling Mountains and the sedimentary evolution of the neighboring Weihe Basin since the Cenozoic era have been influenced by the northeastern expansion of the Qinghai-Tibetan Plateau. These results not only provide key thermochronological constraints for the study of regional tectonic dynamics, but also provide a basis for further discussion of the geological evolution of the northern Qinling Mountains and its tectonic relationship with other regions.